Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

The endothelial Tie1 receptor is ligand-less, but interacts with the Tie2 receptor for angiopoietins (Angpt). Angpt2 is expressed in tumor blood vessels, and its blockade inhibits tumor angiogenesis. Here we found that Tie1 deletion from the endothelium of adult mice inhibits tumor angiogenesis and...

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Main Authors: D’Amico, Gabriela, Korhonen, Emilia A., Anisimov, Andrey, Zarkada, Georgia, Holopainen, Tanja, Hägerling, René, Kiefer, Friedemann, Eklund, Lauri, Sormunen, Raija, Elamaa, Harri, Brekken, Rolf A., Adams, Ralf H., Koh, Gou Young, Saharinen, Pipsa, Alitalo, Kari
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904604/
https://ncbi.nlm.nih.gov/pubmed/24430181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68897
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