Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

The endothelial Tie1 receptor is ligand-less, but interacts with the Tie2 receptor for angiopoietins (Angpt). Angpt2 is expressed in tumor blood vessels, and its blockade inhibits tumor angiogenesis. Here we found that Tie1 deletion from the endothelium of adult mice inhibits tumor angiogenesis and...

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Hauptverfasser: D’Amico, Gabriela, Korhonen, Emilia A., Anisimov, Andrey, Zarkada, Georgia, Holopainen, Tanja, Hägerling, René, Kiefer, Friedemann, Eklund, Lauri, Sormunen, Raija, Elamaa, Harri, Brekken, Rolf A., Adams, Ralf H., Koh, Gou Young, Saharinen, Pipsa, Alitalo, Kari
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904604/
https://ncbi.nlm.nih.gov/pubmed/24430181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68897
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