Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

The endothelial Tie1 receptor is ligand-less, but interacts with the Tie2 receptor for angiopoietins (Angpt). Angpt2 is expressed in tumor blood vessels, and its blockade inhibits tumor angiogenesis. Here we found that Tie1 deletion from the endothelium of adult mice inhibits tumor angiogenesis and...

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Autors principals: D’Amico, Gabriela, Korhonen, Emilia A., Anisimov, Andrey, Zarkada, Georgia, Holopainen, Tanja, Hägerling, René, Kiefer, Friedemann, Eklund, Lauri, Sormunen, Raija, Elamaa, Harri, Brekken, Rolf A., Adams, Ralf H., Koh, Gou Young, Saharinen, Pipsa, Alitalo, Kari
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904604/
https://ncbi.nlm.nih.gov/pubmed/24430181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68897
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