Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1

INTRODUCTION: Defects in the DNA mismatch repair (MMR) protein MLH1 are frequently observed in sporadic and hereditary colorectal cancers (CRC). Affected tumors generate much less metastatic potential than the MLH1 proficient forms. Although MLH1 has been shown to be not only involved in postreplica...

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Detalhes bibliográficos
Main Authors: Hinrichsen, Inga, Ernst, Benjamin Philipp, Nuber, Franziska, Passmann, Sandra, Schäfer, Dieter, Steinke, Verena, Friedrichs, Nicolaus, Plotz, Guido, Zeuzem, Stefan, Brieger, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904401/
https://ncbi.nlm.nih.gov/pubmed/24456667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-11
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