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Promoter Methylation of MLH1, PMS2, MSH2 and p16 Is a Phenomenon of Advanced-Stage HCCs

Epigenetic silencing of tumour suppressor genes has been observed in various cancers. Looking at hepatocellular carcinoma (HCC) specific protein silencing was previously demonstrated to be associated with the Hepatitis C virus (HCV). However, the proposed HCV dependent promoter methylation of DNA mi...

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Autors principals: Hinrichsen, Inga, Kemp, Matthias, Peveling-Oberhag, Jan, Passmann, Sandra, Plotz, Guido, Zeuzem, Stefan, Brieger, Angela
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3882222/
https://ncbi.nlm.nih.gov/pubmed/24400091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0084453
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