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Vitamin D(2) interacts with Human PrP(c) (90–231) and breaks PrP(c) oligomerization in vitro
PrP(sc), the pathogenic isoform of PrP(c), can convert PrP(c) into PrP(sc) through direct interactions. PrP(c) oligomerization is a required processing step before PrP(sc) formation, and soluble oligomers appear to be the toxic species in amyloid-related disorders. In the current study, direct inter...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3904317/ https://ncbi.nlm.nih.gov/pubmed/23857314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.25739 |
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