Binding of bovine T194A PrP(C) by PrP(Sc)-specific antibodies: Potential implications for immunotherapy of familial prion diseases

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases that are based on the misfolding of a cellular prion protein (PrP(C)) into an infectious, pathological conformation (PrP(Sc)). There is proof-of-principle evidence that a prion vaccine is possible but this is tempe...

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Bibliografiske detaljer
Main Authors: Madampage, Claudia A, Määttänen, Pekka, Marciniuk, Kristen, Brownlie, Robert, Andrievskaia, Olga, Potter, Andrew, Cashman, Neil R, Lee, Jeremy S, Napper, Scott
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2013
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904316/
https://ncbi.nlm.nih.gov/pubmed/23787697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.25148
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