Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block

Background and Purpose: Selective nociceptor fibre block is achieved by introducing the cell membrane impermeant sodium channel blocker lidocaine N-ethyl bromide (QX-314) through transient receptor potential V1 (TRPV1) channels into nociceptors. We screened local anaesthetics for their capacity to a...

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Hlavní autoři: Brenneis, C, Kistner, K, Puopolo, M, Jo, S, Roberson, DP, Sisignano, M, Segal, D, Cobos, EJ, Wainger, BJ, Labocha, S, Ferreirós, N, Hehn, C, Tran, J, Geisslinger, G, Reeh, PW, Bean, BP, Woolf, C J
Médium: Artigo
Jazyk:Inglês
Vydáno: The British Pharmacological Society 2014
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3904263/
https://ncbi.nlm.nih.gov/pubmed/24117225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12466
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