Co-application of Lidocaine and the Permanently Charged Sodium Channel Blocker QX-314 Produces a Long-lasting Nociceptive Blockade in Rodents

BACKGROUND: Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin, a transient receptor potential vanilloid 1 (TRPV1) channel agonist. However, the pain evoked by capsaicin before establi...

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Main Authors: Binshtok, Alexander M., Gerner, Peter, Oh, Seog Bae, Puopolo, Michelino, Suzuki, Suzuko, Roberson, David P., Herbert, Teri, Wang, Chi-Fei, Kim, Donghoon, Chung, Gehoon, Mitani, Aya A., Wang, Ging Kuo, Bean, Bruce P., Woolf, Clifford J.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761747/
https://ncbi.nlm.nih.gov/pubmed/19512868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3181a915e7
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