Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality.
The neural cell adhesion molecule (NCAM) is a membrane-associated member of the immunoglobulin superfamily capable of both homophilic and heterophilic binding. To investigate the significance of this binding, a gene targeting strategy in embryonic stem (ES) cells was used to replace the membrane-ass...
Guardat en:
| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
1996
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39038/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8692830/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.13.6421 |
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