Disruption of muREC2/RAD51L1 in Mice Results in Early Embryonic Lethality Which Can Be Partially Rescued in a p53(−/−) Background

muREC2/RAD51L1 is a radiation-inducible gene that regulates cell cycle progression. To elucidate the biological function of muREC2/RAD51L1, the gene was disrupted in embryonic stem cells by homologous recombination. Mice heterozygous for muREC2/RAD51L1 appear normal and fertile; however, no homozygo...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Shu, Zhigang, Smith, Sheryl, Wang, Lijuan, Rice, Michael C., Kmiec, Eric B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85012/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10567591/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.12.8686
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