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TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury

TGF-β is a pathogenic factor in patients with acute respiratory distress syndrome (ARDS), a condition characterized by alveolar edema. A unique TGF-β pathway is described, which rapidly promoted internalization of the αβγ epithelial sodium channel (ENaC) complex from the alveolar epithelial cell sur...

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Bibliografiske detaljer
Main Authors: Peters, Dorothea M., Vadász, István, Wujak, Łukasz, Wygrecka, Małgorzata, Olschewski, Andrea, Becker, Christin, Herold, Susanne, Papp, Rita, Mayer, Konstantin, Rummel, Sebastian, Brandes, Ralph P., Günther, Andreas, Waldegger, Siegfried, Eickelberg, Oliver, Seeger, Werner, Morty, Rory E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903252/
https://ncbi.nlm.nih.gov/pubmed/24324142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306798111
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