TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury

TGF-β is a pathogenic factor in patients with acute respiratory distress syndrome (ARDS), a condition characterized by alveolar edema. A unique TGF-β pathway is described, which rapidly promoted internalization of the αβγ epithelial sodium channel (ENaC) complex from the alveolar epithelial cell sur...

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Detalhes bibliográficos
Main Authors: Peters, Dorothea M., Vadász, István, Wujak, Łukasz, Wygrecka, Małgorzata, Olschewski, Andrea, Becker, Christin, Herold, Susanne, Papp, Rita, Mayer, Konstantin, Rummel, Sebastian, Brandes, Ralph P., Günther, Andreas, Waldegger, Siegfried, Eickelberg, Oliver, Seeger, Werner, Morty, Rory E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903252/
https://ncbi.nlm.nih.gov/pubmed/24324142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1306798111
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