Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability

The zinc finger transcription factor Snail1 regulates epithelial to mesenchymal transition, repressing epithelial markers and activating mesenchymal genes. Snail1 is an extremely labile protein degraded by the cytoplasmic ubiquitin-ligases β-TrCP1/FBXW1 and Ppa/FBXL14. Using a short hairpin RNA scre...

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Detaylı Bibliyografya
Asıl Yazarlar: Viñas-Castells, Rosa, Frías, Álex, Robles-Lanuza, Estefanía, Zhang, Kun, Longmore, Gregory D., García de Herreros, Antonio, Díaz, Víctor M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Molecular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902928/
https://ncbi.nlm.nih.gov/pubmed/24157836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt935
Etiketler: Etiketle
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