Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability

The zinc finger transcription factor Snail1 regulates epithelial to mesenchymal transition, repressing epithelial markers and activating mesenchymal genes. Snail1 is an extremely labile protein degraded by the cytoplasmic ubiquitin-ligases β-TrCP1/FBXW1 and Ppa/FBXL14. Using a short hairpin RNA scre...

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Detalhes bibliográficos
Main Authors: Viñas-Castells, Rosa, Frías, Álex, Robles-Lanuza, Estefanía, Zhang, Kun, Longmore, Gregory D., García de Herreros, Antonio, Díaz, Víctor M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902928/
https://ncbi.nlm.nih.gov/pubmed/24157836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt935
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