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Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation
Snail1 is a central regulator of epithelial cell adhesion and movement in epithelial-to-mesenchymal transitions (EMTs) during embryo development; a process reactivated during cancer metastasis. While induction of Snail1 transcription precedes EMT induction, post-translational regulation of Snail1 is...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3252572/ https://ncbi.nlm.nih.gov/pubmed/21952048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.357 |
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