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A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
Damage to the mitotic spindle and centrosome dysfunction can lead to cancer. To prevent this, cells trigger a succession of checkpoint responses, where an initial mitotic delay is followed by slippage without cytokinesis, spawning tetraploid G1 cells that undergo a p53-dependent G1/S arrest. We desc...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1578695/ https://ncbi.nlm.nih.gov/pubmed/17015431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1447006 |
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