טוען...
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization
Damage to the mitotic spindle and centrosome dysfunction can lead to cancer. To prevent this, cells trigger a succession of checkpoint responses, where an initial mitotic delay is followed by slippage without cytokinesis, spawning tetraploid G1 cells that undergo a p53-dependent G1/S arrest. We desc...
שמור ב:
| Main Authors: | , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Cold Spring Harbor Laboratory Press
2006
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1578695/ https://ncbi.nlm.nih.gov/pubmed/17015431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1447006 |
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