A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

Damage to the mitotic spindle and centrosome dysfunction can lead to cancer. To prevent this, cells trigger a succession of checkpoint responses, where an initial mitotic delay is followed by slippage without cytokinesis, spawning tetraploid G1 cells that undergo a p53-dependent G1/S arrest. We desc...

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Bibliografiske detaljer
Main Authors: Aylon, Yael, Michael, Dan, Shmueli, Ayelet, Yabuta, Norikazu, Nojima, Hiroshi, Oren, Moshe
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2006
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578695/
https://ncbi.nlm.nih.gov/pubmed/17015431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1447006
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