Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation

The Lats2 tumor suppressor protein has previously been implicated in promoting p53 activation in response to mitotic apparatus stress, by preventing Mdm2-driven p53 degradation. We now report that Lats2 also plays a role in an ATR-Chk1-mediated stress checkpoint in response to oncogenic H-Ras. Activ...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Aylon, Yael, Yabuta, Norikazu, Besserglick, Hila, Buganim, Yossi, Rotter, Varda, Nojima, Hiroshi, Oren, Moshe
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795787/
https://ncbi.nlm.nih.gov/pubmed/19855428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.270
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares