Down-regulation of LATS kinases alters p53 to promote cell migration

p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in nontransformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it part...

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Detalles Bibliográficos
Publicado en:Genes Dev
Autores principales: Furth, Noa, Bossel Ben-Moshe, Noa, Pozniak, Yair, Porat, Ziv, Geiger, Tamar, Domany, Eytan, Aylon, Yael, Oren, Moshe
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691886/
https://ncbi.nlm.nih.gov/pubmed/26588988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268185.115
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