Down-regulation of LATS kinases alters p53 to promote cell migration

p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in nontransformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit. Moreover, it part...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Dev
Prif Awduron: Furth, Noa, Bossel Ben-Moshe, Noa, Pozniak, Yair, Porat, Ziv, Geiger, Tamar, Domany, Eytan, Aylon, Yael, Oren, Moshe
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory Press 2015
Pynciau:
Research Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4691886/
https://ncbi.nlm.nih.gov/pubmed/26588988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268185.115
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg