The Hypoxia-controlled FBXL14 Ubiquitin Ligase Targets SNAIL1 for Proteasome Degradation

The transcription factor SNAIL1 is a master regulator of epithelial to mesenchymal transition. SNAIL1 is a very unstable protein, and its levels are regulated by the E3 ubiquitin ligase β-TrCP1 that interacts with SNAIL1 upon its phosphorylation by GSK-3β. Here we show that SNAIL1 polyubiquitylation...

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Detalles Bibliográficos
Main Authors: Viñas-Castells, Rosa, Beltran, Manuel, Valls, Gabriela, Gómez, Irene, García, José Miguel, Montserrat-Sentís, Bàrbara, Baulida, Josep, Bonilla, Félix, de Herreros, Antonio García, Díaz, Víctor M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823521/
https://ncbi.nlm.nih.gov/pubmed/19955572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065995
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