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Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability
The zinc finger transcription factor Snail1 regulates epithelial to mesenchymal transition, repressing epithelial markers and activating mesenchymal genes. Snail1 is an extremely labile protein degraded by the cytoplasmic ubiquitin-ligases β-TrCP1/FBXW1 and Ppa/FBXL14. Using a short hairpin RNA scre...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3902928/ https://ncbi.nlm.nih.gov/pubmed/24157836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt935 |
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