Discovery of Potent and Selective Inhibitors of Toxoplasma gondii Thymidylate Synthase for Opportunistic Infections

[Image: see text] Infection by the parasite Toxoplasma gondii (tg) can lead to toxoplasmosis in immunocompromised patients such as organ transplant, cancer, and HIV/AIDS patients. The bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) enzyme is crucial for nucleotide synthesis in T....

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Egile Nagusiak: Zaware, Nilesh, Sharma, Hitesh, Yang, Jie, Devambatla, Ravi Kumar Vyas, Queener, Sherry F., Anderson, Karen S., Gangjee, Aleem
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2013
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901304/
https://ncbi.nlm.nih.gov/pubmed/24470841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400208v
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