The Interaction of Integrin α(IIb)β(3) with Fibrin Occurs through Multiple Binding Sites in the α(IIb) β-Propeller Domain

The currently available antithrombotic agents target the interaction of platelet integrin α(IIb)β(3) (GPIIb-IIIa) with fibrinogen during platelet aggregation. Platelets also bind fibrin formed early during thrombus growth. It was proposed that inhibition of platelet-fibrin interactions may be a nece...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Podolnikova, Nataly P., Yakovlev, Sergiy, Yakubenko, Valentin P., Wang, Xu, Gorkun, Oleg V., Ugarova, Tatiana P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Cell Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900980/
https://ncbi.nlm.nih.gov/pubmed/24338009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.518126
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg