The Interaction of Integrin α(IIb)β(3) with Fibrin Occurs through Multiple Binding Sites in the α(IIb) β-Propeller Domain

The currently available antithrombotic agents target the interaction of platelet integrin α(IIb)β(3) (GPIIb-IIIa) with fibrinogen during platelet aggregation. Platelets also bind fibrin formed early during thrombus growth. It was proposed that inhibition of platelet-fibrin interactions may be a nece...

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Bibliographische Detailangaben
Hauptverfasser: Podolnikova, Nataly P., Yakovlev, Sergiy, Yakubenko, Valentin P., Wang, Xu, Gorkun, Oleg V., Ugarova, Tatiana P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3900980/
https://ncbi.nlm.nih.gov/pubmed/24338009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.518126
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