Lysophosphatidic acid induces vasodilation mediated by LPA(1) receptors, phospholipase C, and endothelial nitric oxide synthase

Lysophosphatidic acid (LPA) has been implicated as a mediator of several cardiovascular functions, but its potential involvement in the control of vascular tone is obscure. Here, we show that both LPA (18:1) and VPC31143 (a synthetic agonist of LPA(1–3) receptors) relax intact mouse thoracic aorta w...

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Detalhes bibliográficos
Main Authors: Ruisanchez, Éva, Dancs, Péter, Kerék, Margit, Németh, Tamás, Faragó, Bernadett, Balogh, Andrea, Patil, Renukadevi, Jennings, Brett L., Liliom, Károly, Malik, Kafait U., Smrcka, Alan V., Tigyi, Gabor, Benyó, Zoltán
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2014
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898652/
https://ncbi.nlm.nih.gov/pubmed/24249637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-234997
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