Inhibition of LRRK2 kinase activity stimulates macroautophagy()

Leucine Rich Repeat Kinase 2 (LRRK2) is one of the most important genetic contributors to Parkinson's disease. LRRK2 has been implicated in a number of cellular processes, including macroautophagy. To test whether LRRK2 has a role in regulating autophagy, a specific inhibitor of the kinase acti...

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Главные авторы: Manzoni, Claudia, Mamais, Adamantios, Dihanich, Sybille, Abeti, Rosella, Soutar, Marc P.M., Plun-Favreau, Helene, Giunti, Paola, Tooze, Sharon A., Bandopadhyay, Rina, Lewis, Patrick A.
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier Pub. Co 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898616/
https://ncbi.nlm.nih.gov/pubmed/23916833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2013.07.020
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