mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

Leucine rich repeat kinase 2 is a complex enzyme with both kinase and GTPase activities, closely linked to the pathogenesis of several human disorders including Parkinson’s disease, Crohn’s disease, leprosy and cancer. LRRK2 has been implicated in numerous cellular processes; however its physiologic...

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Vydáno v:Sci Rep
Hlavní autoři: Manzoni, Claudia, Mamais, Adamantios, Roosen, Dorien A., Dihanich, Sybille, Soutar, Marc P. M., Plun-Favreau, Helene, Bandopadhyay, Rina, Hardy, John, Tooze, Sharon A., Cookson, Mark R., Lewis, Patrick A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059726/
https://ncbi.nlm.nih.gov/pubmed/27731364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35106
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