Divergent α-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases()

Mutations in LRRK2 are the most common genetic cause of Parkinson's disease (PD). The most prevalent LRRK2 mutation is the G2019S coding change, located in the kinase domain of this complex multi-domain protein. The majority of G2019S autopsy cases feature typical Lewy Body pathology with a cli...

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Main Authors: Mamais, Adamantios, Raja, Meera, Manzoni, Claudia, Dihanich, Sybille, Lees, Andrew, Moore, Darren, Lewis, Patrick A., Bandopadhyay, Rina
Format: Artigo
Sprog:Inglês
Udgivet: Academic Press 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752970/
https://ncbi.nlm.nih.gov/pubmed/23747310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.05.017
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