Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation()

LRRK2 is one of the most important genetic contributors to Parkinson’s disease (PD). Point mutations in this gene cause an autosomal dominant form of PD, but to date no cellular phenotype has been consistently linked with mutations in each of the functional domains (ROC, COR and Kinase) of the prote...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Manzoni, Claudia, Mamais, Adamantios, Dihanich, Sybille, McGoldrick, Phillip, Devine, Michael J., Zerle, Julia, Kara, Eleanna, Taanman, Jan-Willem, Healy, Daniel G., Marti-Masso, Jose-Felix, Schapira, Anthony H., Plun-Favreau, Helene, Tooze, Sharon, Hardy, John, Bandopadhyay, Rina, Lewis, Patrick A.
Формат: Artigo
Язык:Inglês
Опубликовано: Academic Press 2013
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3858825/
https://ncbi.nlm.nih.gov/pubmed/24211199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.10.159
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы