MyD88 signaling in the CNS is required for development of fatty acid induced leptin resistance and diet-induced obesity

Obesity-associated activation of inflammatory pathways represents a key step in the development of insulin resistance in peripheral organs, partially via activation of TLR-4 signaling by fatty acids. Here we demonstrate that palmitate acting in the central nervous system (CNS) inhibits leptin-induce...

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Detalhes bibliográficos
Main Authors: Kleinridders, André, Schenten, Dominik, Könner, A. Christine, Belgardt, Bengt F., Mauer, Jan, Okamura, Tomoo, Wunderlich, F. Thomas, Medzhitov, Ruslan, Brüning, Jens C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898351/
https://ncbi.nlm.nih.gov/pubmed/19808018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.08.013
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