MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10 deficient mice

Commensal bacterial sensing by Toll-like receptors (TLRs) is critical for maintaining intestinal homeostasis, but can lead to colitis in the absence of IL-10. While TLRs are expressed in multiple cell types in the colon, the cell type(s) responsible for the development of colitis currently unknown....

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Autores principales: Hoshi, Namiko, Schenten, Dominik, Nish, Simone A., Walther, Zenta, Gagliani, Nicola, Flavell, Richard A., Reizis, Boris, Shen, Zeli, Fox, James G., Iwasaki, Akiko, Medzhitov, Ruslan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521499/
https://ncbi.nlm.nih.gov/pubmed/23047678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2113
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