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MyD88 signaling in CD4(+) T cells is required to overcome suppression by regulatory T cells

The MyD88 signaling pathway operates in multiple cell types downstream of Toll-like receptors (TLRs) and IL-1 receptor (IL-1R) family members. To investigate the role of the MyD88 pathway in CD4(+) T cell responses, we have generated mice carrying a T cell-specific deletion of MyD88 (MyD88T-KO mice)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Immunity
Prif Awduron: Schenten, Dominik, Nish, Simone A., Yu, Shuang, Yan, Xiting, Lee, Heung Kyu, Brodsky, Igor, Pasman, Lesley, Yordy, Brian, Wunderlich, Thomas, Brüning, Jens C., Zhao, Hongyu, Medzhitov, Ruslan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445716/
https://ncbi.nlm.nih.gov/pubmed/24439266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.10.023
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