DNA methylation determines nucleosome occupancy in the 5′-CpG islands of tumor suppressor genes

Promoter CpG island hypermethylation of tumor suppressor genes is an epigenetic hallmark of human cancer commonly associated with nucleosome occupancy and the transcriptional silencing of the neighboring gene. Nucleosomes can determine the underlying DNA methylation status. Herein, we show that the...

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Detalhes bibliográficos
Main Authors: Portela, A, Liz, J, Nogales, V, Setién, F, Villanueva, A, Esteller, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898323/
https://ncbi.nlm.nih.gov/pubmed/23686312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.162
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