Role of Nucleosomal Occupancy in the Epigenetic Silencing of the MLH1 CpG Island

Epigenetic silencing of tumor suppressor genes is generally thought to involve DNA cytosine methylation, covalent modifications of histones, and chromatin compaction. Here, we show that silencing of the three transcription start sites in the bidirectional MLH1 promoter CpG island in cancer cells inv...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: Lin, Joy C., Jeong, Shinwu, Liang, Gangning, Takai, Daiya, Fatemi, Merhnaz, Tsai, Yvonne C., Egger, Gerda, Gal-Yam, Einav Nili, Jones, Peter A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657456/
https://ncbi.nlm.nih.gov/pubmed/17996647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.10.014
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