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Role of Nucleosomal Occupancy in the Epigenetic Silencing of the MLH1 CpG Island
Epigenetic silencing of tumor suppressor genes is generally thought to involve DNA cytosine methylation, covalent modifications of histones, and chromatin compaction. Here, we show that silencing of the three transcription start sites in the bidirectional MLH1 promoter CpG island in cancer cells inv...
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| Pubblicato in: | Cancer Cell |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4657456/ https://ncbi.nlm.nih.gov/pubmed/17996647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.10.014 |
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