Caricamento...

Role of Nucleosomal Occupancy in the Epigenetic Silencing of the MLH1 CpG Island

Epigenetic silencing of tumor suppressor genes is generally thought to involve DNA cytosine methylation, covalent modifications of histones, and chromatin compaction. Here, we show that silencing of the three transcription start sites in the bidirectional MLH1 promoter CpG island in cancer cells inv...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cancer Cell
Autori principali: Lin, Joy C., Jeong, Shinwu, Liang, Gangning, Takai, Daiya, Fatemi, Merhnaz, Tsai, Yvonne C., Egger, Gerda, Gal-Yam, Einav Nili, Jones, Peter A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657456/
https://ncbi.nlm.nih.gov/pubmed/17996647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.10.014
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !