p120RasGAP Is a Mediator of Rho Pathway Activation and Tumorigenicity in the DLD1 Colorectal Cancer Cell Line

KRAS is mutated in ∼40% of colorectal cancer (CRC), and there are limited effective treatments for advanced KRAS mutant CRC. Therefore, it is crucial that downstream mediators of oncogenic KRAS continue to be studied. We identified p190RhoGAP as being phosphorylated in the DLD1 CRC cell line, which...

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Bibliographic Details
Main Authors: Organ, Shawna L., Hai, Josephine, Radulovich, Nikolina, Marshall, Christopher B., Leung, Lisa, Sasazuki, Takehiko, Shirasawa, Senji, Zhu, Chang-Qi, Navab, Roya, Ikura, Mitsuhiko, Tsao, Ming-Sound
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897622/
https://ncbi.nlm.nih.gov/pubmed/24465899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086103
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