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Effect of a tail piece cysteine deletion on biochemical and functional properties of an epidermal growth factor receptor-directed IgA2 m(1) antibody

Antibodies of human IgA isotype are critical components of the mucosal immune system, but little is known about their immunotherapeutic potential. Compared with IgG antibodies, IgA molecules carry a C-terminal tail piece extension of 18 amino acids with a free cysteine at position 471. This cysteine...

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Main Authors: Brunke, Christina, Lohse, Stefan, Derer, Stefanie, Peipp, Matthias, Boross, Peter, Kellner, Christian, Beyer, Thomas, Dechant, Michael, Royle, Louise, Liew, Li Phing, Leusen, Jeanette HW, Valerius, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896607/
https://ncbi.nlm.nih.gov/pubmed/24492345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.26396
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