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Regulation of complement and modulation of its activity in monoclonal antibody therapy of cancer

The complement system is a powerful tool of the innate immune system to eradicate pathogens. Both in vitro and in vivo evidence indicates that therapeutic anti-tumor monoclonal antibodies (mAbs) can activate the complement system by the classical pathway. However, the contribution of complement to t...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Meyer, Saskia, Leusen, Jeanette HW, Boross, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622586/
https://ncbi.nlm.nih.gov/pubmed/25517299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.29670
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