IgA EGFR antibodies mediate tumour killing in vivo

Currently all approved anti-cancer therapeutic monoclonal antibodies (mAbs) are of the IgG isotype, which rely on Fcgamma receptors (FcγRs) to recruit cellular effector functions. In vitro studies showed that targeting of FcαRI (CD89) by bispecific antibodies (bsAbs) or recombinant IgA resulted in m...

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Hlavní autoři: Boross, Peter, Lohse, Stefan, Nederend, Maaike, Jansen, Johannes Hendrik Marco, van Tetering, Geert, Dechant, Michael, Peipp, Matthias, Royle, Louise, Liew, Li Phing, Boon, Louis, van Rooijen, Nico, Bleeker, Wim K, Parren, Paul W H I, van de Winkel, Jan G J, Valerius, Thomas, Leusen, Jeanette H W
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2013
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944462/
https://ncbi.nlm.nih.gov/pubmed/23918228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201929
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