IgA EGFR antibodies mediate tumour killing in vivo

Currently all approved anti-cancer therapeutic monoclonal antibodies (mAbs) are of the IgG isotype, which rely on Fcgamma receptors (FcγRs) to recruit cellular effector functions. In vitro studies showed that targeting of FcαRI (CD89) by bispecific antibodies (bsAbs) or recombinant IgA resulted in m...

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Main Authors: Boross, Peter, Lohse, Stefan, Nederend, Maaike, Jansen, Johannes Hendrik Marco, van Tetering, Geert, Dechant, Michael, Peipp, Matthias, Royle, Louise, Liew, Li Phing, Boon, Louis, van Rooijen, Nico, Bleeker, Wim K, Parren, Paul W H I, van de Winkel, Jan G J, Valerius, Thomas, Leusen, Jeanette H W
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2013
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944462/
https://ncbi.nlm.nih.gov/pubmed/23918228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201929
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