Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies is to recognize overexpressed or specific tumor antigens and initiate either direct F(ab′)(2)-mediated tumor c...

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Detalles Bibliográficos
Publicado en:Front Immunol
Autores principales: Brandsma, Arianne M., Bondza, Sina, Evers, Mitchell, Koutstaal, Rosanne, Nederend, Maaike, Jansen, J. H. Marco, Rösner, Thies, Valerius, Thomas, Leusen, Jeanette H. W., ten Broeke, Toine
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470253/
https://ncbi.nlm.nih.gov/pubmed/31031746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00704
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