Potent Fc Receptor Signaling by IgA Leads to Superior Killing of Cancer Cells by Neutrophils Compared to IgG

Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies is to recognize overexpressed or specific tumor antigens and initiate either direct F(ab′)(2)-mediated tumor c...

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Udgivet i:Front Immunol
Main Authors: Brandsma, Arianne M., Bondza, Sina, Evers, Mitchell, Koutstaal, Rosanne, Nederend, Maaike, Jansen, J. H. Marco, Rösner, Thies, Valerius, Thomas, Leusen, Jeanette H. W., ten Broeke, Toine
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6470253/
https://ncbi.nlm.nih.gov/pubmed/31031746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00704
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