Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments

BACKGROUND: Tau is a microtubule stabilizing protein and is mainly expressed in neurons. Tau aggregation into oligomers and tangles is considered an important pathological event in tauopathies, such as frontotemporal dementia (FTD) and Alzheimer’s disease (AD). Tauopathies are also associated with d...

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Bibliographische Detailangaben
Hauptverfasser: Levenga, Josien, Krishnamurthy, Pavan, Rajamohamedsait, Hameetha, Wong, Helen, Franke, Thomas F, Cain, Peter, Sigurdsson, Einar M, Hoeffer, Charles A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893396/
https://ncbi.nlm.nih.gov/pubmed/24252661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-34
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