Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments

BACKGROUND: Tau is a microtubule stabilizing protein and is mainly expressed in neurons. Tau aggregation into oligomers and tangles is considered an important pathological event in tauopathies, such as frontotemporal dementia (FTD) and Alzheimer’s disease (AD). Tauopathies are also associated with d...

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Detalhes bibliográficos
Principais autores: Levenga, Josien, Krishnamurthy, Pavan, Rajamohamedsait, Hameetha, Wong, Helen, Franke, Thomas F, Cain, Peter, Sigurdsson, Einar M, Hoeffer, Charles A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893396/
https://ncbi.nlm.nih.gov/pubmed/24252661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-1-34
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