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Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice

Amyloid-β (Aβ) and tau pathologies are intertwined in Alzheimer’s disease, and various immunotherapies targeting these hallmarks are in clinical trials. To determine if tau pathology influences Aβ burden and to assess prophylactic benefits, 3xTg and wild-type mice received tau immunization from 2–6...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Rajamohamedsait, Hameetha, Rasool, Suhail, Rajamohamedsait, Wajitha, Lin, Yan, Sigurdsson, Einar M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719023/
https://ncbi.nlm.nih.gov/pubmed/29213096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17313-1
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