Prophylactic Active Tau Immunization Leads to Sustained Reduction in Both Tau and Amyloid-β Pathologies in 3xTg Mice

Amyloid-β (Aβ) and tau pathologies are intertwined in Alzheimer’s disease, and various immunotherapies targeting these hallmarks are in clinical trials. To determine if tau pathology influences Aβ burden and to assess prophylactic benefits, 3xTg and wild-type mice received tau immunization from 2–6...

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Vydáno v:Sci Rep
Hlavní autoři: Rajamohamedsait, Hameetha, Rasool, Suhail, Rajamohamedsait, Wajitha, Lin, Yan, Sigurdsson, Einar M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719023/
https://ncbi.nlm.nih.gov/pubmed/29213096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17313-1
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