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Autoinhibition of Acetylcholine Binding to Torpedo Electroplax; A Possible Molecular Mechanism for Desensitization
Binding of [(3)H]acetylcholine (measured by equilibrium dialysis) to a particulate preparation of Torpedo electroplax exhibits autoinhibition at concentrations higher than 1 μM. It is suggested that autoinhibition results from acetylcholine binding to regulatory sites on its receptor macromolecules....
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1971
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC389336/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4332243/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.68.9.2006 |
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