HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML

Nur77 and Nor1 are highly conserved orphan nuclear receptors. We have recently reported that nur77(−/−)nor1(−/−) mice rapidly develop acute myeloid leukemia (AML) and that Nur77 and Nor1 transcripts were universally down-regulated in human AML blasts. These findings indicate that Nur77 and Nor1 func...

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Bibliografiska uppgifter
Huvudupphovsmän: Zhou, Liran, Ruvolo, Vivian R., McQueen, Teresa, Chen, Wenjing, Samudio, Ismael J., Conneely, Orla, Konopleva, Marina, Andreeff, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892989/
https://ncbi.nlm.nih.gov/pubmed/23247046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.366
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