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HDAC inhibition by SNDX-275 (Entinostat) restores expression of silenced leukemia-associated transcription factors Nur77 and Nor1 and of key pro-apoptotic proteins in AML
Nur77 and Nor1 are highly conserved orphan nuclear receptors. We have recently reported that nur77(−/−)nor1(−/−) mice rapidly develop acute myeloid leukemia (AML) and that Nur77 and Nor1 transcripts were universally down-regulated in human AML blasts. These findings indicate that Nur77 and Nor1 func...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3892989/ https://ncbi.nlm.nih.gov/pubmed/23247046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.366 |
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