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The histone deacetylase inhibitor entinostat (SNDX-275) induces apoptosis in Hodgkin lymphoma cells and synergizes with Bcl-2 family inhibitors
OBJECTIVE: Based on promising in vitro and in vivo activity of several histone deacetylase inhibitors (HDACi’s) in HL (Hodgkin lymphoma), we investigated SNDX-275, an oral class 1 isoform–selective HDACi in HL-derived cell lines. MATERIALS AND METHODS: Proliferation and cell death were examined by M...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3177003/ https://ncbi.nlm.nih.gov/pubmed/21767511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2011.07.002 |
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